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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal Plant pathology unit - INRA AVIGNON

Pathologie vegetale

Zone de texte éditable et éditée et rééditée

Biological control

Development of biological control agents and durability of biocontrol

The MISTRAL team has a strong experience in selection of biological agents against plant pathogens. Diverse biocontrol agents (Bacillus subtilis, Fusarium sp., Streptomyces sp., plant extracts of Reynoutria sacchalinensis, chitosan) were tested against Botrytis cinerea and Oïdium neolycopersici. Results have shown the efficacy of  Microdochium dimerum to protect the pruning wounds on tomato plants grown under shelters.


Our ongoing studies are focused on the durability of efficacy of biological agents against plant pathogens. Although the capacity of many plant pathogens to develop resistance to chemical pesticides or to overcome varietal resistance is well-known, only few studies have explored their ability to potentially overcome the effect of biocontrol agents and the possible consequences for their field efficacy. The potential of Botrytis cinerea to overcome the efficacy of biological agents was investigated during a thesis defended in 2009. Actually, our main activities concern an other plant pathogen fungus, Sclerotinia sclerotiorum.

Spores of Botrytis cinerea

Spores of Botrytis cinerea

© Pathologie végétale INRAE - Avignon

Sclerotium of Sclerotinia sclerotiorum

Sclerotium of Sclerotinia sclerotiorum

© Pathologie végétale INRAE - Avignon

Oïdium neolycopersici on tomato

Powdey mildew on tomato

© INRAE - PACA - Avignon



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  • Bardin, M., Nicot, P.C. (2020). L'utilisation des microorganismes comme produits de biocontrôle. In : Fauvergue, X., Rusch, A., Barret, M., Bardin, M., Jacquin-Joly, E., Malausa, T., Lannou, C. Biocontrôle. Éléments pour une protection agroécologique des cultures, p. 151-160, Editions Quae, Savoir Faire (Quae)
  • Bardin, M., Pugliese, M. (2020). Biocontrol agents against diseases. In: Gullino, M.-L., Albajes, R., Nicot, P.C., dir., Plant pathology in the 21st century. Integrated pest and disease management in greenhouse crops, Vol. 9, p. 385-407, Springer International Publishing AG, Cham, CHE.
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