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Dernière mise à jour : Mai 2018

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Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs

http://www.paca.inra.fr/institut-sophia-agrobiotech_eng/

FAVERY Bruno

DR - Inra - Senior scientist

FAVERY Bruno
© inra
Molecular and cellular determinants of the compatible interaction between root-knot nematodes and host plants

Education                

  •  2008 Research Supervisor Certificate, University of Nice Sophia Antipolis , France
  • 1999 Ph.D. in Plant Pathology and Molecular Genetics, University of Paris XI Orsay (France).
  • 1995 Master in Plant Pathology, Universities of Paris XI & VI - INAPG (France).

Current Position

  • 1999-present Senior scientist (DR2 permanent position INRA), Plant-Nematode Interaction team – Molecular determinants of the compatible interaction – UMR ISA, INRA-CNRS-UNS Sophia Antipolis.
  • Composition of the group during the last 5 years: 7 post-doc, 3 PhD, 10 master students, 3 contractual engineers, 2 INRA engineers, 1 INRA technician assistant.

Previous Positions

  • 1999-2000 Post-doctoral position - Cell Biology Lab, John Innes Centre Norwich (UK)

Major interests

Among plant-parasitic nematodes, the root-knot nematodes (RKNs) of the Meloidogyne spp. are the most economically important genus. RKN are root parasitic worms able to infect nearly all crop species and have a wide geographic distribution. During infection, RKNs establish and maintain an intimate relationship with the host plant. This includes the creation of a specialized nutritional structure composed of multinucleate and hypertrophied giant cells, which result from the redifferentiation of vascular root cells. Giant cells constitute the sole source of nutrients for the nematode and are essential for growth and reproduction. Hyperplasia of surrounding root cells leads to the formation of the gall or root-knot, an easily recognized symptom of plant infection by RKNs. Secreted effectors produced in nematode salivary glands and injected into plant cells through a specialized feeding structure called the stylet play a critical role in the formation of giant cells. Our group is interested in understanding the complex dialogue between RKNs (M. incognita and M. enterolobii) and their host plants using Arabidopsis and Solanaceae (tomato, tobacco) as model plants. We are studying both partners of the interaction in order to obtain a more comprehensive view of the plant functions corrupted by the pathogens and how RKNs manipulate key plant processes to their own profit. Thus, we characterized key regulators, essential for RKN-induced giant cell ontogenesis and nematode development: a protein implicated in microtubule reorganization (AtMAP65-3) (Caillaud et al., 2008), (homo)glutathione molecules (Baldacci et al, 2012) and the receptor of a signalling peptide PSK (AtPSKR1) (Rodiuc et al., 2015).

We are currently developing projects to (i) characterize RKN-specific effectors and their plant targets; (ii) explore the interplay between transcriptome, small RNAs and methylome in infected roots. Thus, we recently identified a small glycine and cysteine-rich secreted effector, MiSGCR1, involved in plant parasitism (Nguyen et al., 2018) and characterized the implication of a microRNA, miR159, in the plant response to the root-knot nematodes (Medina et al., 2017).

Lab members

  • Michaël Quentin, MCU Nice-Sophia Antipolis
  • Stéphanie Jaubert-Possamai, CR1 INRA
  • Joffrey Mejias, PhD student
  • Yara Noureddine, PhD student
  • Master students

Projects

  • GENOPLANTE 2002-2004 (co-coordinator with P. Abad)
  • ANR/GENOPLANTE AFINDIS 2006-2007«  Arabidopsis Functions Involved in Disease Susceptibility » (coordinator)
  • ANR/GENOMIQUE VEGETALE 2008 SCRIPS “Signaling Peptides and Cytoskeleton Regulators Involved in Plant Disease Susceptibility” (coordinator)
  • German National Susceptibility program, FOR666 "Mechanisms of Compatibility" (2006-2011).
  • INRA-SYNGENTA (2014-2017) et (2017-2019) TARGETOM1 et 2 (co-coordinator with N Peeters)
  • ANR PLANT KBBE 2013 (2014-2018) « NESTOR» (NEmatode Susceptibility Targets fOr durable Resistance) (coordinator G. Taleb)
  • PHC SAKURA 2016 (2016-2017) French –Japan (co-coordinator).
  • Institut Carnot PANDORE (2017-2019) (coordinator Dr S. Jaubert-Possamai)
  • ANR ADMIRE 2018-2022 «  ADaptation of MeloIdogyne to host REsistance » (coordinator Dr P. Abad)

Additional Activities

  • Scientific committees (INRA Sophia-Antipolis Centre ; UMR INRA-UNS-CNRS ISA)
  • PhD promotor (Nice-Sophia Antipolis University: Fabien Jammes; Marie-Cécile Caillaud, Laetitia Paganelli; Chinh-Nghia Nguyen; Yara Noureddine) and promotion commission (Nice-Sophia Antipolis, Marseille, Montpellier, Toulouse (France) and Ghent (Belgium) Universities).
  • Teaching (University of Aix-Marseille III, Ecole Normale Supérieure Lyon, University of Montpellier, Nice Sophia Antipolis, Toulouse).
  • Referee for : Plant Cell; Plant J., MPMI, Planta, Plant Molecular Biology, Molecular Plant Pathology, Eur. J. Plant Pathol., New Phytol., Nematology and for international granting agencies: NSF; NOW; BARD…
  • Publications: 55 articles and reviews (46 in international peer-reviewed journals including Nature Biotechnology, Genes & Development; EMBO J.; Plant Cell; Plant J; Curr. Opin. Biotech.; PloS One, PloS Pathogen, MPMI; Phytopathology; Mol. Plant Pathol.; J. Plant Physiol.) and 5 patents.

Publications in the past 3 years

  1. Nguyen, C-N., Perfus-Barbeoch-Zurletto, L., Quentin, M., Zhao, J., Magliano, M., Marteu, N., Da Rocha, M., Nottet, N., Abad, P. & Favery, B. (2018) A root-knot nematode small glycine and cysteine-rich secreted effector, MiSGCR1, is involved in plant parasitism. New Phytologist 217: 687-699. PMID: 29034957.
  2. Allasia, V., Industri, B., Ponchet, M., Quentin, M., Favery, B.* and Keller, H.* (2018) Quantification of salicylic acid (SA) and SA-glucosides in Arabidopsis thaliana. Bio-protocol 8(10): e2844. DOI: 10.21769/BioProtoc.2844. * co-corresponding authors.
  3. Jaouannet, M., Nguyen, C-N., Quentin, M., Jaubert-Possamai, S., Rosso, M.-N. and Favery, B. (2018). In situ Hybridization (ISH) in preparasitic and parasitic stages of the plant-parasitic nematodes Meloidogyne spp. Bio-protocol 8(6): e2766. DOI:10.21769/BioProtoc.2766.
  4. Medina, C., Da Rocha, M., Magliano, M., Raptopoulo, A., Revel, B., Marteu, N., Magnone, V., Cabrera, J., Barcala, M., Pereira da Silva, A., Escobar, C., Abad, P., Favery, B., Jaubert-Possamai, S. (2017). Characterisation of microRNAs from Arabidopsis galls highlights a role for miR159 in the plant response to the root-knot nematodes Meloidogyne incognita. New Phytologist 216: 882–896.
  5. Hanemian, M., Barlet, X., Sorin, C., Koste A., Yadeta, K.A., Keller, H., Favery, B., Simon, R., Thomma B. P., Hartmann C., Crespi M., Marco, Y., Tremousaygue, D. and Deslandes L. (2016). Arabidopsis CLAVATA1 and CLAVATA2 receptors contribute to Ralstonia solanacearum pathogenicity through a miR169-dependent pathway. New Phytologist 211(2):502-15. doi: 10.1111/nph.13913.
  6. Cabrera J., Barcala M., García A., Rio-Machín A., Medina C., Jaubert-Possamai S., Favery B., Maizel A., Ruiz-Ferrer V., Fenoll C., Escobar C (2016) Differentially expressed plant small RNAs in Arabidopsis galls formed by Meloidogyne javanica: a functional role for miR390 and its TAS3-derived tasiRNAs. New Phytologist, 209(4):1625-1640.
  7. Quentin, M, Baurès, I., Caillaud M.C., Allasia, V., Hok, S., Hoefle, C., Hückelhoven, R., Abad, P., Keller, H.*, Favery, B.* (*co-corresponding authors) (2016). The Arabidopsis MICROTUBULE-ASSOCIATED PROTEIN MAP65-3 supports infection by filamentous biotrophic pathogens by downregulating salicylic acid-dependent defenses. J. Exp. Bot. 67 (6):1731-43. doi: 10.1093/jxb/erv564.
  8. Favery, B, Quentin, M., Jaubert-Possamai, S.; Abad, P. (2016). Gall-forming root-knot nematodes hijack key plant cellular functions to induce multinucleate and hypertrophied feeding cells. J. Insect Physiol. Vol 84, 60-69.
  9. Rodiuc N, Barlet X, Hok S, Engler G, Perfus-Barbeoch L, Seassau A, Marteu, N., de Almeida-Engler J, Panabières F, Abad P, Kemmerling B, Marco Y, Favery B.*, Keller H.* (*co-corresponding authors) (2016) Evolutionarily distant pathogens require the Arabidopsis phytosulfokine signalling pathway to establish disease. Plant Cell and Environment, 39, 1396–1407. DOI: 10.1111/pce.12627

Five other relevant publications

  1. Damiani, I., Baldacci-Cresp, F., Hopkins, J., Andrio, E., Balzergue, S., Lecomte, P., Puppo, A., Abad, P., Favery*, B.and Hérouart*, D (co-corresponding authors) (2012). Plant Genes Involved in Harbouring Symbiotic Rhizobia or Pathogenic Nematode. New Phytologist, 194: 511–522.
  2. Baldacci-Cresp, F., Chang, C., Maucourt, M., Deborde, C., Hopkins, J., Lecomte, P., Brouquisse, R., Moing, A., Abad, P., Hérouart, D., Puppo, A., Favery, B. and Frendo, P. (2012). (Homo)glutathione Deficiency Impairs Root-knot Nematode Development in Medicago truncatula. PloS Pathogen, 8(1): e1002471..
  3. Banora, M.Y.; Rodiuc, N., Baldacci-Cresp, F.; Smertenko, A., Bleve-Zacheo, T., Melillo, M.T., Karimi, M., Hilson, P., Evrard, J.L., Favery, B., Engler, G., Abad, P., de Almeida-Engler, J. (2011) Feeding Cells Induced by Phytoparasitic Nematodes Requireγ-Tubulin Ring Complex for Microtubule Reorganization. PloS Pathogen, 7(12): e1002343..
  4. Abad, P., Gouzy, J., Aury, J.-M., Castagnone-Sereno, P., Danchin, E.G.J., Deleury, E., Perfus-Barbeoch, L. et al. (2008) Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita. Nature Biotechnology, 26, 909-915.
  5. Caillaud, M.C., Lecomte, P., Jammes, F., Quentin, M., Pagnotta, S., Andrio, E., de Almeida-Engler, J., Marfaing, N., Gounon, P., Abad, P. and Favery, B. (2008a) MAP65-3 Microtubule-Associated Protein is Essential for Nematode-Induced Giant Cell Ontogenesis in Arabidopsis. Plant Cell, 20, 423-437.

Add-on value/Technology transfer/Patents

  • WO2015/033328A1. Danchin, E., Abad, P., Perfus Barbeoch, L., Favery, B. (2015).”Method for reducing the plant parasitic nematode infestation level in a plant“; based on the European Patent EP20130306233. Applicant : Genoplante – Valor.
  • WO2012/017067. Rodiuc N, Marco Y, Favery B, Keller H (2012). “Plants resistant to pathogens and methods for production thereof (Phytosulfokines and their receptor as novel breeding targets for plant resistance to diverse pests)”; based on the European Patent EP10305870 and patent N° PCT/EP2011. Applicant : Genoplante – Valor.
  • WO2008/139334. Favery et al (2007/2008) Brevet déposé par Génoplante Valor “Method for increasing the resistance of a plant to endoparasitic nematode” “; based on the European Patent EP07290610.0. Applicant : Genoplante – Valor.
  • WO2005/063989 Favery, B, Abad P. “Promoter nucleotidic sequences inducible by infection by pathogens”. Applicant : Genoplante – Valor.
  • French patent 237155/D.17538/FFP. Abad P., Favery, B. (1998). Applicant : INRA (N°9807379) 11/06/ 1998  "Gènes de réponse aux nématodes".

Email : Bruno.Favery@inrae.fr