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Dernière mise à jour : Mai 2018

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Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs

http://www.paca.inra.fr/institut-sophia-agrobiotech_eng/

DANCHIN Etienne

DR - Inra - Senior scientist

DANCHIN Etienne
© inra
Comparative genomics and evolution of plant parasitism in nematodes.
Scientific referent of the bioinformatics platform.

Biosketch

After a Master of Science in Bioinformatics, Structural Biochemistry and Genomics (BBSG) obtained from the Aix-Marseille University (Marseille, France), I actually started my research career by a PhD Thesis  in the Evolutionary Biology & Modeling laboratory of Dr. Pierre Pontarotti (EBM),  CNRS / Aix-Marseille Université. During my thesis, I have focused my research on evolutionarily conserved genomic regions across various different bilaterian animals (including human, drosophila and zebrafish). Identification of conserved regions has allowed conceptual reconstruction of the original region in the last common ancestor of these species. I defended my PhD thesis in 2004 and obtained a doctorate degree in Bioinformatics and Genomics.

I continued my research activity in the same lab (EBM) as an assistant professor at the Aix-Marseille University. During this period I have mainly researched genes widely conserved during evolution from plants to insects and nematodes but absent from vertebrate genomes (including the human genome). I have been able to identify various gene families whose absence in vertebrate genomes could be related to actual losses of capabilities such as synthesis of some amino-acids or carbohydrates.

In 2005, I joined the "Architecture et Fonction des Macromolécules Biologiques" laboratory (AFMB),  CNRS / Aix-Marseille University as a postdoc. During this postdoc, in the Glycogenomics team of Dr. B. Henrissat, I have been studying structural and functional classification of Carbohydrate-Active enZymes (or CAZymes). My main research interest here was to detect, classify and compare CAZyme repertoires in fungal genomes. At this occasion, I have been involved in a variety of genome annotation consortia, including with world-class genome sequencing centers like the Broad Institute or the Joint Genome Institute. One of the main finding of my research during my postdoc was that CAZyme repertoires appear to reflect the lifestyle of fungal species. For instance, fungi that are phytopathogens tend to have similar arsenals of CAZymes for the degradation of carbohydrates that compose the plant cell wall.

In 2007, I have been hired by INRA as a research associate in Sophia-Antipolis (French Riviera, France).  As a member of the "Plant / Nematode Interaction" team, my research mainly focuses on comparative genomics and evolution of plant parasitism in nematodes.

Research Interests

  • Comparative and evolutionary genomics of plant-parasitic nematodes.
  • Emergence and evolution of plant-parasitism in nematodes.
  • Horizontal gene transfers
  • Parasitism genes in plant nematodes
  • Genomic plasticity in the absence of sexual reproduction
  • Genomic architecture in species with asexual reproduction.

Publications and scientific production

My publications in peer-reviewed journals as well as my contributions to scientific meetings and conferenes are listed in my personal website, available here.

Email : Etienne.Danchin@inrae.fr