Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free: https://www.ghostery.com/fr/products/

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site: http://www.youronlinechoices.com/fr/controler-ses-cookies/, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Realytics
Google Analytics
Spoteffects
Optimizely

Targeted advertising cookies

DoubleClick
Mediarithmics

The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at cil-dpo@inra.fr or by post at:

INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Institut Sophia Agrobiotech Logo_INRAE_noir Logo Université Côte d'Azur CNRS

Home page

Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs

http://www.paca.inra.fr/institut-sophia-agrobiotech_eng/

Equipe ATIP-Avenir DEB

DEB – Developmental timing, Environment, and Behaviors

Our interest focuses on understanding how does the environment interact with the genes to times the Juvenile-to-adult DevelopmentalTransition (JDT) and its associated behaviors. The JDT  (Metamorphosis/ puberty) determines the reproductive ability for a given species. Therefore, uncovering the mechanism timing this developmental transition is essential to improve pest management efficiency but also, in the case of human, to battle against adverse health consequences caused by earlier puberty.

 Background:
JTD

Environmental modulation of the Neuroendocrine Circuitry: Development and Behaviors. In insects and mammals, the juvenile-to-adult transition is trigger by a burst of steroid hormones production instructed by the brain neuroendocrine circuitry. The precise timing of hormonal burst is defined in the brain by a dynamic interplay between genes and the environment, which take place from the embryo till the juvenile ages. During this interplay, the brain is the final tissue, which integrates internal and environmental signals to triggers the onset of JDT. Due to this long-term back-and-forth between internal and external milieu, our knowledge of the regulation of the neurohormonal circuitry activity is incomplete. Therefore, our main interest focuses on understanding how do the environmental and internal cues modulate the activity of the neuroendocrine circuitry during the developmental period to times JDT and coordinates its associated behaviors.

Biological Model:

We use Drosophila melanogaster as our favorite model due to its ease use for genetic modifications that enabled the identification of novel conserved genes. The life cycle of Drosophila can be classified in four distinct phases: the embryonic developmental phase, juvenile growth phase, prepupa and pupa maturation phase (metamorphosis) and adult stage. Sexual maturation in Drosophila and other holometabolous insects occurs during pupariation stages through a process named metamorphosis.

 

Scientific originality of the team:

Mammals-Droso

Despite the physiological divergence between insects and mammals, studies have shown that insect metamorphosis and mammalian puberty exhibit similar neuroendocrine design principles and pathways, suggesting the existence of common regulatory signals controlling JDT onset between them. Indeed, we just identified a conserved brain circuitry regulating steroid hormones production and the timing of JDT in both mammals and Drosophila melanogaster. This, in combination with the genetic amenability of flies, has made Drosophila a top-choice model for our team to study the instructive role of the brain on timing juvenile-to-adult developmental transition.

 

Research topics and objectives:

SIgnals

(i) Define the environmental signals timing JDT: 

By performing unbiased genetic RNAi screens, we will identify the environmental signals involved in the activation of the neuroendocrine circuit at the onset of JDT. Besides, D. melanogaster shows a close relation with D. suzukii, suggesting that genes identified in this project could be conserved between those species, offering possible new targets for the development of bio-pesticides. 

 

(ii) Assess the communication between the neurons and the gland cells: 

The neuroendocrine circuit projects its axon into the prothoracic gland, where it secretes a neuropeptide to stimulate the production of steroid hormones. We take advantage of this simple brain-gland model to assess how do neuropeptides stimulate glands; and whether adverse environmental conditions could strengthen or weaken this communication to define JDT timing.

 

signals2

(iii) Determine the coordination between the developmental and behavioral programs. We are currently developing different strategies to test how does the behavioral program is set up and coordinated with the developmental program. Indeed, in most animals, JDT is accompanied by multiple behavioral changes leading towards exploring and engaging in social complexities.

 

 

Scientific and social issues

Understanding the mechanism timing the onset of this transition is essential for public health but also agriculture. For instance, slow-down of the exponential insect population growth is crucial to improve pest management strategies, and this also impacts medical research if the insect is a vector for dangerous diseases like dengue. Moreover, knowledge about the JDT timing mechanism is indispensable to battle against a current trend for earlier initiation of puberty, which causes several adverse health consequences.