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Dernière mise à jour : Mai 2018

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Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs

The organization of single-cell genome into TADs and chromatin nanodomains.

Jeudi 1er juillet à 11h00 - Sophia Antipolis - INRAE PACA - Visioconférence

Séminaire scientifique
As part of the scientific animation of ISA, the BES team is inviting Frédéric Bantignies from the "Institut de Génétique Humaine" of Montpellier.

Participer à la réunion Zoom:

ID de réunion : 879 9028 5107
Code secret : 289733
Pour vous connecter depuis un téléphone fixe:
1. Composer le +33 1 8699 5831
2. Entrer l'ID 879 9028 5107 puis #
3. Entrer le code 289733 puis #


Deciphering the rules of genome folding in the cell nucleus is essential to understand its function. Topologically Associating Domains (TADs) represent a new chromosomal entity detectable in interphase nuclei by cell population analysis such as High-throughput Chromosome Conformation Capture (Hi-C). Highly conserved through evolution, TADs partition the genome at the sub-megabase scale and have been proposed to delimit regulatory landscapes where functional interactions between genes and distal cis-regulatory elements may occur. However, the structure of TADs and their association with genome activity in individual cells are still under debate.To investigate the folding of the chromatin fiber at the sub-megabase level in single cell, we have been using Oligopaint FISH probes combined with super-resolution microscopy (3D-SIM). This approach allowed us to better define the physical nature of TADs as well as their correspondence to the epigenetic landscape. I will present our most recent data concerning the folding of chromosome into TADs and nanodomains in both Drosophila and mouse ES cells, and highlight some common and distinct features of genome organization in these organisms.