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Dernière mise à jour : Mai 2018

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Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs

A novel insecticidal molecule extracted from Alpinia galanga to control a pest insect, Spodoptera frugiperda

Vendredi 13 décembre 11h00 - Sophia Antipolis - Inra PACA - Salle A010

Séminaire scientifique
Dans le cadre de l'animation scientifique Torranis Ruttanaphan de l'équipe IDnous présentera ses travaux


Spodoptera frugiperda (J.E. Smith), a highly polyphagous insect pest from America, has recently invaded and widely spread throughout Africa and Asia. Effective and environmentally safe tools are needed for successful pest management. Natural molecules extracted from plants offer this possibility. Our study aimed at determining the insecticide efficacy of a new molecule extracted from Alpinia galanga rhizome, the 1'S-1'-Acetoxychavicol acetate (ACA). The toxicity of ACA was evaluated by topical application on early third-instar larvae of S. frugiperda and compared to the toxicity of a commercial neem-based insecticide, NeemAzal-T/S (containing azadirachtin as its active ingredient). Our results showed that ACA caused significant larval growth inhibition and larval developmental abnormalities. In order to further explore the effects of this molecule, experiments have been performed on the cellular model, the Sf9 cells. ACA exhibited higher toxicity on Sf9 cells as compared to azadirachtin and was 38-folds less toxic on non-target cells (mammalian HepG2 cells). Inhibition of cell proliferation was observed at sublethal concentrations of ACA and was associated to cellular morphological changes and nuclear condensation. Regarding detoxification genes, ACA treatment correlates with the under-expression of five genes (including CYP9A26, GSTO2, GSTD1, CCE006a, CCE006b) and the over-expression of two genes (CYP9A31 and CYP9A32). This first study on the effects of ACA on cells and larvae of S. frugiperda provides evidences that ACA can be a promising candidate to be developed as a botanical insecticide for a sustainable management of S. frugiperda