Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Institut Sophia Agrobiotech Logo Marque Etat - République Française Logo_INRAE_noir Logo Université Côte d'Azur CNRS

Home page

Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs

Entomologia Generalis

06 February 2018

Entomologia Generalis
Widespread resistance of the aphid Myzus persicae to pirimicarb across China, and insights on ace2 mutation frequency in this species.


Abstract Modified acetylcholinesterase (AChE) phenotype (MACE) caused by a mutation in the ACHE gene (ace2) leading to pirimicarb resistance in Myzus persicae (Sulzer) has been reported worldwide. Pirimicarb resistance levels and AChE susceptibility to this insecticide were investigated in 19 field populations collected in six provinces of China, in compared to a susceptible laboratory population, five of the 19 field populations were susceptible to pirimicarb with resistance factors (RF) < 5, whereas the other 14 populations were found to be resistant to pirimicarb (RF ranging from 16.3 to 101.9). The residual activity of AChE after exposure to pirimicarb varied significantly from 10.7% to 91.4% among these populations, three of them exhibited extremely low AChE sensitivity to the pirimicarb. In addition, residual AChE activity was positively correlated with increased resisitance to pirimicarb. Nine populations showing a wide range of RF values were selected to investigate S431F mutation frequency in ace2. The mutation frequencies in these populations were all > 85%. The RF values of the populations were positively correlated with the recorded frequencies of S431F mutation. These results demonstrate that MACE is strongly involved in the resistance to pirimicarb observed in populations of M. persicae in China.


Acetylcholinesterase, Mutation, Insecticide resistance, ace2, Carbamate

Xiaolan, L., Qiuling, T., Yongdan, L., Mateus R, C., Pei, L., and Xiwu, G. (2017). Widespread resistance of the aphid Myzus persicae to pirimicarb across China, and insights on ace2 mutation frequency in this species. Entomologia Generalis 285–299. DOI: 10.1127/entomologia/2017/0480

Site : View online >>