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Dernière mise à jour : Mai 2018

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Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs

Targets against plant-parasitic worms without risk for the environment (IPN Team)

Root-knot nematodes are globally the most aggressive and damaging plant-parasitic nematodes.

Chemical nematicides have so far constituted the most efficient control measures against these agricultural pests. Because of their toxicity for the environment and danger for human health, chemical nematicides have now been banned from use. Consequently, new and more specific control means, safe for the environment and human health are urgently needed to avoid worldwide proliferation of these devastating plant-parasites. Thanks to bioinformatics tools, we have developed an evolutionary approach by comparing, all the coding sequences contained in numerous genomes to identify genes present in plant pathogens, but absent in non-harmful species such as insect pollinators, for instance. These genes constitute a set of targets potentially useful to the stakes described previously. From a set of M. incognita genes conserved in other plant pathogens, but absent in non-harmful species genomes, a functional annotation identified 993 proteins potentially secreted by the nematode which could play a role in the molecular dialogue with the host plant. Among these proteins, we showed that the inactivation of 12 of these genes has leaded to significant reduction in nematode infestation symptoms

Sequences comparisons between various species allowed identification of specific genes present only in plant pathogen genomes. These genes constitute interesting targets for the elaboration of new environment-friendly strategies to fight against these pests.

Sequences comparisons between various species allowed identification of specific genes present only in plant pathogen genomes. These genes constitute interesting targets for the elaboration of new environment-friendly strategies to fight against these pests.

  • Danchin EGJ, Arguel MJ, Campan-Fournier A, Perfus-Barbeoch L, Magliano M, Rosso MN, Da Rocha M, Da Silva C, Nottet N.,Labadie K, Guy J, Artiguenave F, Abad P. (2013) Identification of Novel Target Genes for Safer and More Specific Control of Root-Knot Nematodes from a Pan-Genome Mining. PLoS Pathogens, DOI: 10.1371/journal. ppat.10037 45.
  • Danchin EGJ, Abad P, Perfus-Barbeoch L. (2013). Method for reducing the plant-parasitic nematode infestation level in a plant. Brevet n° F151600041/EP/OEB déposé en nov 2013, pris par GENOPLANTEVALOR