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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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LEBARON Caroline

AI Inrae - Engineer Assistant

Equipe REDD

Functions - Thematic Research

Research technician in Resistance to virus team

- Study of natural and induced allele of multigene family (eIF4E factors) to understand resistance mechanism of virus. 

- Natural allele characterization on Tomato.

- Implementation technical on Molecular Biology and on pathology for candidate resistance gene test.

- Implementation of biotechnology approaches to generate new resistance systems (TILLING, CRISPR/CAS9).


Career and Cursus:


2019 - untill now: Engineer Assistant at Inrae GAFL, ReDD team

2010-2018: Research technician at INRAe Avignon, Resistance to virus team.

2007-2010: Engineer assistant at CNRS UPS 3044 « Baculovirus and therapy » St Christol Lez Ales. Cloning and development of human antibodies by Baculovirus system.


2019: Master Sciences et Vie at Nice (VAE)

2006-2007 : Professional Licence of Molecular Biology (IUT des Pays de l’Adour)

2004-2006 : Diplôme Universitaire Technologique Génie Biologique option ABB (IUT du Maine)


Skills :

Molecular Biology

-          Genotyping (dCAPS and KASPar)

-          Nucleic acid extraction (ARN, ADN)

-          Cloning (Bacteria, Gateway, CRISPR)

-          Yeast: protein-protein interaction by yeast two-hybrid, complementation to test functionality gene.

Cellular Biology

-          Transformation on tomato by Agrobacteria

Plant and Phytopathology

-          Crossing on Tomato and Pepper.

-          Maintenance of viral strain

-          Resistance test: virus inoculation on tomato, pepper and Arabidopsis thaliana, and virus detection by immunoenzymatics method (ELISA).




Moury B, Lebaron C, Szadkowski M, Ben Khalifa M, Girardot G, Bolou Bi BA, Koné D, Nitiema LW, Fakhfakh H, Gallois JL. Knock-out mutation of eukaryotic initiation factor 4E2 (eIF4E2) confers resistance to pepper veinal mottle virus in tomato. Virology. 2020 Jan 2;539:11-17. doi: 10.1016/j.virol.2019.09.015. Epub 2019 Oct 3. PMID: 31622792.


LebaronC, Rosado A, Sauvage C, Gauffier C, German-Retana S, Moury B, Gallois JL. A new eIF4E1 allele characterized by RNAseq data mining is associated with resistance to potato virus Y in tomato albeit with a low durability. J Gen Virol. 2016 Nov;97(11):3063-3072. doi: 10.1099/jgv.0.000609.

Gauffier C., Lebaron C., Constant C., Moquet F., Bonnet G., Moretti A.,  Caranta C., Gallois JL. (2016). A TILLING approach to generate broad-spectrum resistance to potyviruses in tomato is hampered by eIF4E gene redundancy. Plant J. 2016 Mar;85(6):717-29. doi: 10.1111/tpj.13136


Jacobin-Valat MJ, Laroche-Traineau J, Larivière M, Mornet S, Sanchez S, Biran M, Lebaron C, Boudon J, Lacomme S, Cérutti M, Clofent-Sanchez G. (2015). Nanoparticles functionalised with an anti-platelet human antibody for in vivo detection of atherosclerotic plaque by magnetic resonance imaging. Nanomedicine. 2015 May;11(4):927-37. doi: 10.1016/j.nano.2014.12.006. Epub 2015 Feb 12.

Lebaron C, Sauvage C, Gauffier C, Moury B, Gallois JL (2015). A new eIF4E allele characterized by RNAseq in tomato is associated with resistance to potyviruses. 15ème rencontre de virologie végétale, Aussois, France, Poster.

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