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Identification of a new mechanism of resistance to Potyvirus involving intracellular vesicle formation in melon.

Identification of a new mechanism of resistance to Potyvirus
Aimeric Agaoua, Vincent Rittener, Christelle Troadec, Cécile Desbiez, Abdelhafid Bendahmane, Frédéric Moquet, and Catherine Dogimont.

In plants, introgression of genetic resistances is a proven strategy for developing new resistant lines. While host proteins involved in genome replication and cell-to-cell movement are widely studied, other cellular mechanisms responsible for viral infection remain underestimated. Endosomal sorting complexes required for transport (ESCRT) proteins play a key role in membrane trafficking in plants and are involved in the replication of several plant RNA viruses. We have demonstrated for the first time the role of the ESCRT protein CmVPS4 as a novel susceptibility factor for the Potyvirus watermelon mosaic virus (WMV) in melon. By screening a worldwide collection of melons, we identified three different alleles carrying non-synonymous substitutions in CmVps4. Two of these alleles were shown to be associated with WMV resistance. Using a complementation approach, we demonstrated that resistance is due to a single non-synonymous substitution in the allele CmVps4P30R. This work opens up new avenues of research on a new family of host factors required for virus infection and new targets for resistance.

See also

Agaoua A., Bendahmane A., Moquet F., Dogimont C., 2021. Membrane Trafficking Proteins: A New Target to Identify Resistance to Viruses in Plants. Plants 10 (10): DOI: 10.3390/plants10102139.


Agaoua A., Rittener V., Troadec C., Desbiez C., Bendahmane A., Moquet F., Dogimont C., 2022. A single substitution in Vacuolar protein sorting 4 is responsible for resistance to watermelon mosaic virus in melon. Journal of Experimental Botany: DOI: 10.1093/jxb/erac135.